SELECTED PUBLICATIONS

M. A. Santos, S. Wu, M. Regenold, C. Allen, D.E. Goertz, K. Hynynen, “Novel fractionated ultra-short thermal exposures with MRI-guided focused ultrasound for treating tumors with thermosensitive drugs,” Science Advances (2020). [In press]

C. D. Morrone, P. Bazzigaluppi, T. L. Beckett, M. E. Hill, M. M. Koletar, B. Stefanovic, J. McLaurin, "Regional Differences in Alzheimer’s Disease Pathology Confounds Behavioural Rescue After amyloid-beta Attenuation," Brain, 2020 Jan 1;143(1):359-373. https://academic.oup.com/brain/article/143/1/359/5647334

C. Pellow, M. A. O’Reilly, K. Hynynen, G. Zheng, D. E. Goertz, “Simultaneous Intravital Optical and Acoustic Monitoring of Ultrasound-Triggered Nanobubble Generation and Extravasation,” Nano Lett., 2020 May 6; 20(6): 4512–4519. https://pubs.acs.org/doi/full/10.1021/acs.nanolett.0c01310

J. Mester, P. Bazzigaluppi, I. Weisspapir, A. Dorr, T. Beckett,  M. Koletar, J.G. Sled, B. Stefanovic, “In vivo Neurovascular Response to Focused Photoactivation of Channelrhodopsin-2,” NeuroImage, 2019 Jan 19. pii: S1053-8119(19)30036-9. https://pubmed.ncbi.nlm.nih.gov/30669007/

M.M. Koletar, A. Dorr, M. E. Brown, J. McLaurin B. Stefanovic, "Refinement of a chronic cranial window implant in the rat for longitudinal in vivo two–photon fluorescence microscopy of neurovascular function," Scientific Reports, 2019 Apr 2, 9(5499).https://www.nature.com/articles/s41598-019-41966-9

P. Bazzigaluppi, C. Adams, M.  Koletar, A. Dorr, A. Pikula, P. Carlen, B. Stefanovic, “Oophorectomy reduces estradiol levels and long-term spontaneous neurovascular recovery in a female rat model of focal ischemic stroke,” Frontiers in Molecular Neuroscience, 2018 Sept 13. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6146137/

P. Bazzigaluppi  E. Lake, C. Beckett, M. Koletar, I. Weisspapir, S. Heinen, J. Mester, A.Lai, R. Janik, A. Dorr, J. McLaurin, G.J. Stanisz, P. Carlen, B. Stefanovic,  “Imaging the effects of Beta-Hydroxybutyrate on peri-infarct neurovascular function and metabolism,” Stroke, 2018 Sep; 49(9): 2173-2181.  https://www.ahajournals.org/doi/10.1161/STROKEAHA.118.020586

C. Adams, P. Bazzigaluppi, T.L.Beckett, J.Bishay, I. Weisspapir, J. Steinman, L. Hirschler, J.M. Warnking, E.L. Barbier, J. McLaurin, J.G. Sled, B. Stefanovic, "Chronic Neurovascular Dysfunction in Preclinical Model of Repeated Mild Traumatic Brain Injury", Theranostics, 2018 Sep 09; 8(17): 4824-4836. https://www.thno.org/v08p4824.htm

C. T. Poon, K. Shah, C. Lin, R. Tse, K. K .Kim, S. Mooney, I. Aubert, B. Stefanovic, K. Hynynen, “Time Course of Focused Ultrasound Effects on β-amyloid Plaque Pathology in the TgCRND8 Mouse Model of Alzheimer's Disease,” Scientific Report, 2018 Sep 19;8(1):14061.  https://www.nature.com/articles/s41598-018-32250-3

P. Bazzigaluppi, T.L. Beckett, M.M. Koletar, A.Y. Lai AY, I.L. Joo, M.E. Brown, P.L. Carlen, J. McLaurin, B. Stefanovic, “Early stage attenuation of phase amplitude coupling in the hippocampus and medial prefrontal cortex in a transgenic rat model of AD,” Journal of Neurochemistry, 2018 Mar;144(5):669-679. https://pubmed.ncbi.nlm.nih.gov/28777881/

P. Bazzigaluppi, I. Weisspapir, B. Stefanovic, L. Leybaert, P.L. Carlen, “Astrocytic gap junction blockade markedly increases extracellular potassium without causing seizures in the mouse neocortex,” Neurobiol Dis, 2017 May;101:1-7. https://pubmed.ncbi.nlm.nih.gov/28007587/

A. Dorr, L.A.M. Thomason, M.M. Koletar, I. Joo, J. Steinman, L.S. Cahill, J.G. Sled, B. Stefanovic, “Effects of voluntary exercise on structure and function of cortical microvasculature”, Journal of Cerebral Blood Flow and Metabolism, 2017 Mar;37(3):1046-1059. https://journals.sagepub.com/doi/10.1177/0271678X16669514

I.L. Joo, A.Y. Lai, P. Bazzigaluppi, M.M. Koletar, A. Dorr, M.E. Brown, L.A. Thomason, J.G. Sled, J. McLaurin, B. Stefanovic, “Early neurovascular dysfunction in a transgenic rat model of Alzheimer’s disease”, Sci Rep. 2017 Apr 12;7:46427. https://www.nature.com/articles/srep46427

P. Bazzigaluppi, A. E. Amini, I. Weisspapir, B. Stefanovic, P. Carlen, “Hungry neurons: metabolic insights on seizure dynamics”, International Journal of Molecular Sciences, 2017 Oct 28; 18(11). pii: E2269. https://pubmed.ncbi.nlm.nih.gov/29143800/

E. Cherin, J. Melis, R.W. Bourdeau, M. Yin, D.M. Kochmann, M.G. Shapiro, F.S. Foster, “Acoustic behavior of Halobacterium salinarium gas vesicles in the 12.5-27.5 MHz frequency range:  experiments and modeling,”  Ultrasound Medicine and Biology, 43(5):1016-1030 (2017). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5385285/

M. A. Santos, D.E. Goertz, K. Hynynen, “Focused Ultrasound Hyperthermia Mediated Drug Delivery Using Thermosensitive Liposomes and Visualized With in vivo Two-Photon Microscopy,” Theranostics, 2017 Jul 7;7(10):2718-2731. https://pubmed.ncbi.nlm.nih.gov/28819458/

E. Lake, P. Bazzigaluppi, J.Mester, L.A. Thomason, R. Janik, M. Brown, J. McLaurin, P.L. Carlen, D. Corbett, G.J. Stanisz, B. Stefanovic, “Neurovascular unit remodeling in the subacute stage of stroke recovery,” NeuroImage, 2017 Feb 1;146:869-882. https://pubmed.ncbi.nlm.nih.gov/27664828/

J.Steinman, B. Stefanovic, M. Koletar, J.Sled, “3D morphological analysis of the mouse cerebral vasculature: comparison of in vivo and ex vivo methods,”  PLOS ONE, 2017 Oct 20; 12(10):e0186676. doi: 10.1371/journal.pone.0186676. eCollection 2017.  PONE-D-16-47874R2 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5650181/

P.S. Sheeran, Y. Daghighi, K. Yoo, R. Williams, E. Cherin, F.S. Foster, P.N. Burns, “Image-guided ultrasound characterization of volatile sub-micron phase-shift droplets in the 20-40 Mhz frequency range,” Ultrasound in Medicine and Biology, 42:795-807 (2016). https://www.sciencedirect.com/science/article/abs/pii/S0301562915006766

C.N. Acconcia, B.Y.C. Leung, D.E. Goertz, “The microscale evolution of the erosion front of blood clots exposed to ultrasound stimulated microbubbles,” The Journal of the Acoustical Society of America, 30 Apr 2016, 139(5):EL135. https://europepmc.org/article/med/27250198

A.Y. Lai, A. Dorr, L.A.M. Thomason, M.M. Koletar, J.G. Sled, B. Stefanovic, J. McLaurin. “Venular degeneration leads to vascular dysfunction in a transgenic model of Alzheimer's disease,” Brain, 138(Pt 4):1046-58 (2016). https://pubmed.ncbi.nlm.nih.gov/25688079/

C. Acconcia, B.Y.C. Leung, A. Manjunath, D.E. Goertz, “The effect of short duration ultrasound pulses on the interaction between individual microbubbles and fibrin clots,” Ultrasound in Medicine & Biology, 2015 Oct;41(10):2774-82. https://pubmed.ncbi.nlm.nih.gov/26116160/

J.M. Denbeigh, B.A. Nixon,  J.J.Y. Lee, M. Jerkic, P.A. Marsden, M. Letarte, M.C. Puri, F.S. Foster, “Contrast-enhanced molecular ultrasound differentiates Endoglin genotypes in mouse embryos,”  Angiogenesis, 18:69-81 (2015). https://link.springer.com/article/10.1007/s10456-014-9447-0